| 1. Round | 19/03/2022 | FK Isloch Minsk | - | FK Slutsk | 1:2 |  |
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| 2. Round | 02/04/2022 | Dinamo Brest | - | FK Isloch Minsk | 2:2 | ||||
| 3. Round | 10/04/2022 | FK Isloch Minsk | - | Shakhter Soligorsk | 1:1 | ||||
| 4. Round | 16/04/2022 | FK Isloch Minsk | - | Neman Grodno | 1:1 | ||||
| 5. Round | 23/04/2022 | Energetik-BGU Minsk | - | FK Isloch Minsk | 1:2 | ||||
| 6. Round | 01/05/2022 | FK Isloch Minsk | - | FK Minsk | 2:0 | ||||
| 7. Round | 07/05/2022 | Arsenal Dzerzhinsk | - | FK Isloch Minsk | 1:3 | ||||
| 8. Round | 15/05/2022 | FK Isloch Minsk | - | FK Slaviya Mozyr | 0:2 | ||||
| 9. Round | 21/05/2022 | Belshina Bobruisk | - | FK Isloch Minsk | 2:1 | ||||
| 10. Round | 27/05/2022 | FK Isloch Minsk | - | Dnepr Mogilev | 3:2 | ||||
| 11. Round | 18/06/2022 | BATE Borisov | - | FK Isloch Minsk | 0:1 | ||||
| 12. Round | 25/06/2022 | FK Isloch Minsk | - | FK Gomel | 1:1 | ||||
| 13. Round | 02/07/2022 | Dinamo Minsk | - | FK Isloch Minsk | 1:2 | ||||
| 27. Round | 24/10/2022 | FK Gomel | - | FK Isloch Minsk | 3:1 | ||||
| 29. Round | 06/11/2022 | FK Vitebsk | - | FK Isloch Minsk | 1:3 | ||||
| 30. Round | 12/11/2022 | FK Isloch Minsk | - | Torpedo-BelAZ Zhodino | 3:0 |
Russia