| 16. Round | 06/08/2022 | FK Slutsk | - | FK Isloch Minsk | 2:4 |  |
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| 17. Round | 13/08/2022 | FK Isloch Minsk | - | Dinamo Brest | 1:2 | ||||
| 18. Round | 21/08/2022 | Shakhter Soligorsk | - | FK Isloch Minsk | 1:0 | ||||
| 19. Round | 27/08/2022 | Neman Grodno | - | FK Isloch Minsk | 1:0 | ||||
| 20. Round | 03/09/2022 | FK Isloch Minsk | - | Energetik-BGU Minsk | 2:3 |  |
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| 21. Round | 10/09/2022 | FK Minsk | - | FK Isloch Minsk | 1:5 | |
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| 22. Round | 17/09/2022 | FK Isloch Minsk | - | Arsenal Dzerzhinsk | 2:1 | ||||
| 24. Round | 09/10/2022 | FK Isloch Minsk | - | Belshina Bobruisk | 2:0 | ||||
| 25. Round | 15/10/2022 | Dnepr Mogilev | - | FK Isloch Minsk | 0:2 | ||||
| 26. Round | 20/10/2022 | FK Isloch Minsk | - | BATE Borisov | 0:0 | ||||
| 27. Round | 24/10/2022 | FK Gomel | - | FK Isloch Minsk | 3:1 | ||||
| 29. Round | 06/11/2022 | FK Vitebsk | - | FK Isloch Minsk | 1:3 |
Belarus