| 1. Round | 25/04/2021 | OKC Energy FC | - | FC Tulsa | 1:3 | ||||
| 2. Round | 02/05/2021 | OKC Energy FC | - | Atlanta United II | 0:1 | ||||
| 2. Round | 08/05/2021 | Sporting Kansas City 2 | - | OKC Energy FC | 1:1 |  |
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| 2. Round | 16/05/2021 | OKC Energy FC | - | Atlanta United II | 2:2 | ||||
| 2. Round | 27/05/2021 | Birmingham Legion | - | OKC Energy FC | 1:0 | ||||
| 4. Round | 01/08/2021 | Louisville City FC | - | OKC Energy FC | 2:1 | ||||
| 5. Round | 08/08/2021 | OKC Energy FC | - | Memphis 901 | 4:1 | ||||
| 5. Round | 12/08/2021 | Atlanta United II | - | OKC Energy FC | 2:2 | ||||
| 5. Round | 15/08/2021 | Indy Eleven | - | OKC Energy FC | 2:1 | ||||
| 5. Round | 29/08/2021 | OKC Energy FC | - | Rio Grande Valley FC | 2:1 | ||||
| 6. Round | 04/09/2021 | Sporting Kansas City 2 | - | OKC Energy FC | 3:0 | ||||
| 6. Round | 19/09/2021 | Birmingham Legion | - | OKC Energy FC | 1:1 | ||||
| 6. Round | 26/09/2021 | OKC Energy FC | - | Indy Eleven | 2:0 | ||||
| 6. Round | 30/09/2021 | OKC Energy FC | - | Indy Eleven | 1:1 | ||||
| 7. Round | 03/10/2021 | OKC Energy FC | - | San Antonio FC | 0:1 | ||||
| 7. Round | 25/10/2021 | El Paso Locomotive | - | OKC Energy FC | 4:0 |
Japan