| 5. Round | 18/10/2020 | OFI Heraklion | - | Panathinaikos | 2:2 | ||||
| 6. Round | 25/10/2020 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
| 7. Round | 01/11/2020 | AEK Athen | - | OFI Heraklion | 2:1 | ||||
| 8. Round | 08/11/2020 | OFI Heraklion | - | Olympiakos Piraeus | 0:2 | ||||
| 9. Round | 23/11/2020 | Volos NFC | - | OFI Heraklion | 1:4 | ||||
| 11. Round | 06/12/2020 | OFI Heraklion | - | Apollon Smyrnis | 0:2 | ||||
| 12. Round | 12/12/2020 | AE Lárissa | - | OFI Heraklion | 0:1 |  |
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| 13. Round | 19/12/2020 | OFI Heraklion | - | Aris Saloniki | 0:3 | ||||
| 15. Round | 07/01/2021 | OFI Heraklion | - | Lamia | 2:0 | ||||
| 16. Round | 10/01/2021 | Atromitos | - | OFI Heraklion | 0:0 | ||||
| 23. Round | 21/02/2021 | PAS Giannina | - | OFI Heraklion | 1:0 |
Greece