| 1. Round | 23/08/2021 | Apollon Limassol | - | Ethnikos Achna | 4:2 | ||||
| 4. Round | 24/09/2021 | Doxa Katokopias | - | Ethnikos Achna | 0:0 | ||||
| 6. Round | 18/10/2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 7. Round | 23/10/2021 | Ethnikos Achna | - | AEL Limassol | 2:2 | ||||
| 8. Round | 31/10/2021 | AEK Larnaca | - | Ethnikos Achna | 1:0 | ||||
| 9. Round | 07/11/2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | ||||
| 11. Round | 26/11/2021 | Ethnikos Achna | - | Olympiakos Nikosia | 1:0 | ||||
| 12. Round | 06/12/2021 | Ethnikos Achna | - | Apollon Limassol | 0:1 | ||||
| 14. Round | 18/12/2021 | Ethnikos Achna | - | Anorthosis Famagusta | 0:2 | ||||
| 16. Round | 08/01/2022 | Aris Limassol | - | Ethnikos Achna | 2:1 | ||||
| 18. Round | 22/01/2022 | AEL Limassol | - | Ethnikos Achna | 1:0 | ||||
| 19. Round | 29/01/2022 | Ethnikos Achna | - | AEK Larnaca | 0:0 | ||||
| 20. Round | 07/02/2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 |  |
Cyprus