| 1. Round | 09/04/2022 | Grobiņas SC | - | Valmiera FC II | 1:3 | ||||
| 2. Round | 17/04/2022 | Rīgas Futbola skola II | - | Grobiņas SC | 2:3 | ||||
| 3. Round | 24/04/2022 | Grobiņas SC | - | Rēzeknes FA | 6:1 | ||||
| 4. Round | 01/05/2022 | FS Jelgava | - | Grobiņas SC | 4:0 | ||||
| 5. Round | 08/05/2022 | Grobiņas SC | - | FK Tukums 2000 II | 6:0 |  |
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| 6. Round | 15/05/2022 | Grobiņas SC | - | Saldus SS/Leevon | 4:1 | ||||
| 7. Round | 22/05/2022 | FK Dinamo Rīga | - | Grobiņas SC | 0:3 | |
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| 9. Round | 19/06/2022 | FK Smiltene | - | Grobiņas SC | 0:4 | ||||
| 10. Round | 02/07/2022 | Grobiņas SC | - | Skanstes SK | 0:3 | ||||
| 11. Round | 16/07/2022 | AFA Olaine | - | Grobiņas SC | 3:1 | |
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| 13. Round | 30/07/2022 | Riga FC II | - | Grobiņas SC | 2:1 | |
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| 15. Round | 20/08/2022 | Grobiņas SC | - | Rīgas Futbola skola II | 2:3 | ||||
| 17. Round | 04/09/2022 | Grobiņas SC | - | FS Jelgava | 0:0 | ||||
| 18. Round | 11/09/2022 | FK Tukums 2000 II | - | Grobiņas SC | 2:3 | ||||
| 19. Round | 17/09/2022 | Saldus SS/Leevon | - | Grobiņas SC | 0:4 | |
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| 24. Round | 29/10/2022 | Grobiņas SC | - | AFA Olaine | 6:0 | ||||
| 25. Round | 05/11/2022 | Salaspils FC | - | Grobiņas SC | 2:3 | ||||
| 26. Round | 13/11/2022 | Grobiņas SC | - | Riga FC II | 5:3 | |
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