1. Round | 14/08/2021 | Floriana FC | - | St. Luċija FC | 2:2 | ||||
2. Round | 20/08/2021 | Sliema Wanderers | - | Floriana FC | 0:0 | ||||
3. Round | 11/09/2021 | Floriana FC | - | Valletta FC | 3:0 | ||||
4. Round | 19/09/2021 | Birkirkara FC | - | Floriana FC | 1:1 | ||||
5. Round | 25/09/2021 | Floriana FC | - | Hamrun Spartans | 1:2 | ||||
6. Round | 16/10/2021 | Balzan FC | - | Floriana FC | 1:2 | ||||
8. Round | 31/10/2021 | Floriana FC | - | Gżira United | 2:1 | ||||
9. Round | 20/11/2021 | Gudja United | - | Floriana FC | 0:1 | ||||
10. Round | 27/11/2021 | Floriana FC | - | Sirens FC | 1:2 | ||||
11. Round | 05/12/2021 | Hibernians FC | - | Floriana FC | 0:0 | ||||
12. Round | 11/12/2021 | St. Luċija FC | - | Floriana FC | 1:3 | ||||
13. Round | 19/12/2021 | Floriana FC | - | Sliema Wanderers | 2:0 | ||||
14. Round | 17/01/2022 | Valletta FC | - | Floriana FC | 0:2 | ||||
15. Round | 23/01/2022 | Floriana FC | - | Birkirkara FC | 1:0 | ||||
17. Round | 06/02/2022 | Floriana FC | - | Balzan FC | 2:1 | ||||
20. Round | 26/02/2022 | Floriana FC | - | Gudja United | 2:0 | ||||
21. Round | 06/03/2022 | Sirens FC | - | Floriana FC | 0:3 | ||||
22. Round | 12/03/2022 | Floriana FC | - | Hibernians FC | 1:4 |