| 5. Round | 01/10/2022 | Żebbuġ Rangers | - | Marsaxlokk FC | 0:3 |  |
|||
| 6. Round | 08/10/2022 | Marsaxlokk FC | - | St. Luċija FC | 2:2 |  |
|||
| 7. Round | 17/10/2022 | Gudja United | - | Marsaxlokk FC | 1:2 | |
|
||
| 8. Round | 23/10/2022 | Marsaxlokk FC | - | Birkirkara FC | 1:0 | |
|||
| 9. Round | 30/10/2022 | Marsaxlokk FC | - | Hibernians FC | 1:1 | ||||
| 10. Round | 05/11/2022 | Pietá Hotspurs | - | Marsaxlokk FC | 1:1 | ||||
| 11. Round | 13/11/2022 | Marsaxlokk FC | - | Sirens FC | 1:2 | ||||
| 12. Round | 03/12/2022 | Floriana FC | - | Marsaxlokk FC | 1:1 | |
|
||
| 14. Round | 16/12/2022 | Marsaxlokk FC | - | Hamrun Spartans | 0:1 | ||||
| 15. Round | 08/01/2023 | Mosta FC | - | Marsaxlokk FC | 2:1 | ||||
| 16. Round | 22/01/2023 | Marsaxlokk FC | - | Gżira United | 0:3 | ||||
| 17. Round | 29/01/2023 | Balzan FC | - | Marsaxlokk FC | 0:0 | ||||
| 18. Round | 05/02/2023 | Marsaxlokk FC | - | Żebbuġ Rangers | 1:1 | ||||
| 19. Round | 12/02/2023 | St. Luċija FC | - | Marsaxlokk FC | 0:1 | ||||
| 20. Round | 18/02/2023 | Marsaxlokk FC | - | Gudja United | 1:1 | ||||
| 21. Round | 05/03/2023 | Birkirkara FC | - | Marsaxlokk FC | 1:1 | ||||
| 22. Round | 11/03/2023 | Hibernians FC | - | Marsaxlokk FC | 1:3 | ||||
| 23. Round | 02/04/2023 | Marsaxlokk FC | - | Pietá Hotspurs | 1:2 |
Italy