| 6. Round | 11/09/2010 | Lierse SK (old) | - | KAA Gent | 2:2 | ||||
| 7. Round | 18/09/2010 | KVC Westerlo | - | Lierse SK (old) | 2:0 | ||||
| 8. Round | 22/09/2010 | Lierse SK (old) | - | RSC Anderlecht | 1:1 |  |
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| 9. Round | 25/09/2010 | Sporting Charleroi | - | Lierse SK (old) | 0:1 | ||||
| 10. Round | 02/10/2010 | Lierse SK (old) | - | Cercle Brugge | 0:1 | ||||
| 11. Round | 16/10/2010 | Germinal Beerschot | - | Lierse SK (old) | 1:1 | |
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| 12. Round | 23/10/2010 | Lierse SK (old) | - | SV Zulte Waregem | 0:0 | ||||
| 13. Round | 30/10/2010 | KAS Eupen | - | Lierse SK (old) | 2:2 | ||||
| 14. Round | 06/11/2010 | Lierse SK (old) | - | Sporting Lokeren | 2:2 | ||||
| 15. Round | 13/11/2010 | Club Brugge KV | - | Lierse SK (old) | 2:0 | ||||
| 16. Round | 20/11/2010 | Lierse SK (old) | - | Sint-Truidense VV | 1:2 | ||||
| 17. Round | 27/11/2010 | Standard Liège | - | Lierse SK (old) | 7:0 | |
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| 19. Round | 12/12/2010 | KV Kortrijk | - | Lierse SK (old) | 3:1 | |
Belgium