| 1. Round | 17/08/2011 | Sportkring Sint-Niklaas | - | KSK Heist | 1:1 |  |
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| 5. Round | 18/09/2011 | KSK Heist | - | Eendracht Aalst | 1:3 | ||||
| 6. Round | 24/09/2011 | Sporting Charleroi | - | KSK Heist | 1:1 | ||||
| 7. Round | 02/10/2011 | KSK Heist | - | Lommel United | 1:1 | ||||
| 8. Round | 08/10/2011 | Standaard Wetteren | - | KSK Heist | 0:3 | |
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| 9. Round | 15/10/2011 | KAS Eupen | - | KSK Heist | 4:1 | |
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| 10. Round | 23/10/2011 | KSK Heist | - | CS Visé | 1:1 | ||||
| 11. Round | 29/10/2011 | Royal Antwerp FC | - | KSK Heist | 0:3 | ||||
| 12. Round | 06/11/2011 | KSK Heist | - | FCV Dender EH | 2:2 |  |
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| 13. Round | 12/11/2011 | AFC Tubize | - | KSK Heist | 2:3 | ||||
| 14. Round | 20/11/2011 | KSK Heist | - | KVK Tienen | 1:2 | |
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| 15. Round | 26/11/2011 | KSV Roeselare | - | KSK Heist | 2:1 | |
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| 18. Round | 18/12/2011 | KSK Heist | - | Sportkring Sint-Niklaas | 4:3 | ||||
| 19. Round | 07/01/2012 | R. White Star Woluwe FC | - | KSK Heist | 0:0 | ||||
| 20. Round | 15/01/2012 | KSK Heist | - | FC Brussels | 1:2 | ||||
| 21. Round | 22/01/2012 | RBD Borinage | - | KSK Heist | 1:2 | ||||
| 22. Round | 29/01/2012 | KSK Heist | - | Sporting Charleroi | 1:2 | ||||
| 33. Round | 20/04/2012 | KV Oostende | - | KSK Heist | 4:0 |
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