| 1. Round | 14/08/2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Round | 21/08/2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 3. Round | 12/09/2021 | Balzan FC | - | Birkirkara FC | 1:2 | ||||
| 4. Round | 19/09/2021 | Birkirkara FC | - | Floriana FC | 1:1 | ||||
| 5. Round | 26/09/2021 | Gżira United | - | Birkirkara FC | 1:1 |  |
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| 6. Round | 16/10/2021 | Birkirkara FC | - | Gudja United | 2:0 | |
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| 7. Round | 24/10/2021 | Sirens FC | - | Birkirkara FC | 3:2 | ||||
| 8. Round | 30/10/2021 | Birkirkara FC | - | Hibernians FC | 1:1 | |
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| 14. Round | 19/01/2022 | Birkirkara FC | - | Balzan FC | 3:2 | ||||
| 17. Round | 06/02/2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Round | 13/02/2022 | Birkirkara FC | - | Sirens FC | 1:1 | |
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| 20. Round | 27/02/2022 | Birkirkara FC | - | St. Luċija FC | 2:3 | ||||
| 21. Round | 06/03/2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Round | 12/03/2022 | Birkirkara FC | - | Valletta FC | 1:1 |
Malta