| 20. Round | 13/02/2022 | RWD Molenbeek | - | KMSK Deinze | 1:0 | ||||
| 21. Round | 19/02/2022 | Waasland-Beveren | - | RWD Molenbeek | 1:0 | ||||
| 22. Round | 27/02/2022 | RWD Molenbeek | - | Lierse Kempenzonen | 3:1 | ||||
| 23. Round | 06/03/2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 24. Round | 12/03/2022 | Lommel SK | - | RWD Molenbeek | 0:0 | ||||
| 25. Round | 20/03/2022 | RWD Molenbeek | - | Excelsior Virton | 3:0 | ||||
| 27. Round | 09/04/2022 | RWD Molenbeek | - | Waasland-Beveren | 2:1 |  |
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| 28. Round | 16/04/2022 | KVC Westerlo | - | RWD Molenbeek | 2:2 |
Belgium