| 2. Round | 30/07/2021 | Kolos Kovalivka | - | Metalist 1925 Kharkiv | 1:0 | ||||
| 5. Round | 22/08/2021 | Kolos Kovalivka | - | FK Oleksandriya | 0:1 | ||||
| 6. Round | 28/08/2021 | Dinamo Kiev | - | Kolos Kovalivka | 7:0 | ||||
| 7. Round | 12/09/2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 |  |
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| 8. Round | 18/09/2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | ||||
| 9. Round | 24/09/2021 | Kolos Kovalivka | - | Vorskla Poltava | 0:1 | |
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| 10. Round | 02/10/2021 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 | ||||
| 13. Round | 31/10/2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | ||||
| 14. Round | 07/11/2021 | Kolos Kovalivka | - | Shakhtar Donetsk | 1:3 | ||||
| 15. Round | 21/11/2021 | Desna Chernigov | - | Kolos Kovalivka | 0:1 | |
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| 3. Round | 24/11/2021 | FC Mynai | - | Kolos Kovalivka | 1:1 | |
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| 17. Round | 04/12/2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 | ||||
| 18. Round | 12/12/2021 | Kolos Kovalivka | - | FC Mynai | 2:1 |
Ukraine