| 1. Round | 26/01/2019 | Patriotas FC | - | Independiente Medellín | 2:1 | ||||
| 2. Round | 30/01/2019 | Independiente Medellín | - | La Equidad | 1:1 |  |
|||
| 3. Round | 02/02/2019 | Atlético Junior | - | Independiente Medellín | 3:2 | ||||
| 4. Round | 10/02/2019 | Independiente Medellín | - | Unión Magdalena | 1:1 | ||||
| 5. Round | 16/02/2019 | América de Cali | - | Independiente Medellín | 3:0 | ||||
| 9. Round | 10/03/2019 | Independiente Medellín | - | Santa Fe | 1:0 | ||||
| 10. Round | 16/03/2019 | Independiente Medellín | - | Atlético Nacional | 2:2 | ||||
| 12. Round | 31/03/2019 | Millonarios | - | Independiente Medellín | 3:2 | ||||
| 13. Round | 05/04/2019 | Independiente Medellín | - | Once Caldas | 1:1 | |
|||
| 14. Round | 07/04/2019 | Deportivo Pasto | - | Independiente Medellín | 1:0 | |
|||
| 15. Round | 14/04/2019 | Independiente Medellín | - | Atlético Bucaramanga | 4:0 | ||||
| 17. Round | 20/04/2019 | Independiente Medellín | - | Jaguares de Córdoba | 3:0 | ||||
| 8. Round | 25/04/2019 | Atlético Nacional | - | Independiente Medellín | 1:0 | |
|||
| 18. Round | 28/04/2019 | Alianza Petrolera | - | Independiente Medellín | 1:1 | |
Colombia