| 1. Round | 24/01/2020 | Deportes Tolima | - | Independiente Medellín | 2:2 | ||||
| 2. Round | 28/01/2020 | Independiente Medellín | - | Águilas Doradas | 2:1 | ||||
| 5. Round | 15/02/2020 | América de Cali | - | Independiente Medellín | 2:0 |  |
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| 6. Round | 22/02/2020 | Independiente Medellín | - | Atlético Nacional | 1:3 | |
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| 7. Round | 29/02/2020 | Atlético Nacional | - | Independiente Medellín | 1:1 |  |
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| 10. Round | 28/09/2020 | Independiente Medellín | - | Deportivo Pereira | 1:1 | ||||
| 11. Round | 05/10/2020 | La Equidad | - | Independiente Medellín | 1:0 | ||||
| 14. Round | 15/10/2020 | Independiente Medellín | - | Jaguares de Córdoba | 1:1 |  |
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| 15. Round | 19/10/2020 | Deportivo Pasto | - | Independiente Medellín | 2:1 |  |
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| 18. Round | 06/11/2020 | Santa Fe | - | Independiente Medellín | 3:0 | ||||
| 19. Round | 10/11/2020 | Independiente Medellín | - | Atlético Bucaramanga | 1:0 | |
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| 20. Round | 14/11/2020 | Envigado FC | - | Independiente Medellín | 2:1 | |
Colombia