| 10. Round | 03/09/2021 | Vélez Sarsfield II | - | Unión de Santa Fe II | 2:2 | ||||
| 18. Round | 25/10/2021 | Vélez Sarsfield II | - | Boca Juniors II | 1:2 | ||||
| 20. Round | 05/11/2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 24. Round | 06/12/2021 | Vélez Sarsfield II | - | Patronato de Paraná II | 1:0 | ||||
| 25. Round | 09/12/2021 | Platense II | - | Vélez Sarsfield II | 3:1 |
Argentina