| 1. Round | 26/07/2015 | RSC Anderlecht | - | Waasland-Beveren | 3:2 | ||||
| 2. Round | 02/08/2015 | Oud-Heverlee Leuven | - | RSC Anderlecht | 0:2 |  |
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| 3. Round | 09/08/2015 | RSC Anderlecht | - | KAA Gent | 1:1 | ||||
| 4. Round | 16/08/2015 | KV Oostende | - | RSC Anderlecht | 3:1 | ||||
| 6. Round | 30/08/2015 | KVC Westerlo | - | RSC Anderlecht | 0:3 | ||||
| 7. Round | 13/09/2015 | RSC Anderlecht | - | KRC Genk | 0:0 | ||||
| 8. Round | 20/09/2015 | Sporting Charleroi | - | RSC Anderlecht | 1:1 | ||||
| 9. Round | 27/09/2015 | RSC Anderlecht | - | Sint-Truidense VV | 1:0 | ||||
| 10. Round | 04/10/2015 | RSC Anderlecht | - | KV Mechelen | 1:1 | ||||
| 11. Round | 18/10/2015 | SV Zulte Waregem | - | RSC Anderlecht | 0:4 |  |
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| 12. Round | 25/10/2015 | RSC Anderlecht | - | Club Brugge KV | 3:1 | |
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| 14. Round | 01/11/2015 | RSC Anderlecht | - | Royal Mouscron-Péruwelz | 2:0 | ||||
| 15. Round | 08/11/2015 | Standard Liège | - | RSC Anderlecht | 1:0 | ||||
| 17. Round | 29/11/2015 | RSC Anderlecht | - | Oud-Heverlee Leuven | 3:2 | |
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| 20. Round | 20/12/2015 | Club Brugge KV | - | RSC Anderlecht | 1:4 | ||||
| 16. Round | 23/12/2015 | Sporting Lokeren | - | RSC Anderlecht | 1:1 | ||||
| 21. Round | 27/12/2015 | RSC Anderlecht | - | KVC Westerlo | 2:1 |
Belgium