| 1. Round | 11/07/2022 | Orsomarso SC | - | Deportes Quindío | 0:4 | ||||
| 2. Round | 17/07/2022 | Deportes Quindío | - | Real Santander | 2:0 | ||||
| 3. Round | 25/07/2022 | Bogotá FC | - | Deportes Quindío | 1:2 | ||||
| 7. Round | 13/08/2022 | Deportes Quindío | - | Fortaleza FC | 1:0 | ||||
| 8. Round | 20/08/2022 | Barranquilla FC | - | Deportes Quindío | 1:1 | ||||
| 15. Round | 03/10/2022 | Llaneros FC | - | Deportes Quindío | 1:0 | ||||
| 16. Round | 08/10/2022 | Deportes Quindío | - | Leones FC | 3:2 |  |
Colombia