| 1. Round | 07/08/2010 | Southampton FC | - | Plymouth Argyle | 0:1 | ||||
| 2. Round | 14/08/2010 | Plymouth Argyle | - | Carlisle United | 1:1 |  |
|||
| 3. Round | 21/08/2010 | Walsall FC | - | Plymouth Argyle | 2:1 | |
|||
| 4. Round | 28/08/2010 | Plymouth Argyle | - | Peterborough United | 0:3 | ||||
| 6. Round | 11/09/2010 | Colchester United | - | Plymouth Argyle | 1:1 |  |
|||
| 8. Round | 25/09/2010 | Rochdale AFC | - | Plymouth Argyle | 1:1 | ||||
| 9. Round | 28/09/2010 | Swindon Town | - | Plymouth Argyle | 2:3 | ||||
| 11. Round | 09/10/2010 | Plymouth Argyle | - | Charlton Athletic | 2:2 | |
|||
| 12. Round | 16/10/2010 | Notts County | - | Plymouth Argyle | 2:0 |
England