| 5. Round | 03/02/2019 | Lobos BUAP | - | CF Pachuca | 1:1 | ||||
| 8. Round | 24/02/2019 | CF América | - | Lobos BUAP | 3:0 | ||||
| 9. Round | 03/03/2019 | Lobos BUAP | - | Pumas UNAM | 2:1 |  |
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| 11. Round | 16/03/2019 | Monarcas Morelia | - | Lobos BUAP | 1:1 | ||||
| 12. Round | 31/03/2019 | Lobos BUAP | - | Puebla FC | 0:4 | ||||
| 13. Round | 07/04/2019 | Deportivo Guadalajara | - | Lobos BUAP | 0:1 | ||||
| 17. Round | 05/05/2019 | Deportivo Toluca | - | Lobos BUAP | 4:0 |
Colombia