| 1. Round | 18/02/2022 | Wexford FC | - | Treaty United | 1:5 | ||||
| 2. Round | 25/02/2022 | Cobh Ramblers | - | Wexford FC | 2:3 |  |
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| 3. Round | 04/03/2022 | Wexford FC | - | Athlone Town | 2:1 | ||||
| 14. Round | 02/05/2022 | Wexford FC | - | Bray Wanderers | 1:1 | ||||
| 15. Round | 07/05/2022 | Longford Town | - | Wexford FC | 2:1 | ||||
| 16. Round | 13/05/2022 | Wexford FC | - | Galway United | 0:4 | ||||
| 17. Round | 20/05/2022 | Cork City | - | Wexford FC | 1:1 | ||||
| 19. Round | 10/06/2022 | Wexford FC | - | Treaty United | 1:1 | ||||
| 20. Round | 17/06/2022 | Cobh Ramblers | - | Wexford FC | 0:3 | ||||
| 21. Round | 24/06/2022 | Wexford FC | - | Longford Town | 2:1 | ||||
| 22. Round | 27/06/2022 | Bray Wanderers | - | Wexford FC | 2:2 | ||||
| 29. Round | 20/08/2022 | Longford Town | - | Wexford FC | 1:0 | ||||
| 30. Round | 02/09/2022 | Wexford FC | - | Waterford FC | 2:2 | ||||
| 31. Round | 09/09/2022 | Athlone Town | - | Wexford FC | 2:0 | ||||
| 33. Round | 30/09/2022 | Wexford FC | - | Bray Wanderers | 4:2 |  |
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| 34. Round | 07/10/2022 | Cork City | - | Wexford FC | 0:0 | ||||
| 35. Round | 14/10/2022 | Wexford FC | - | Galway United | 0:0 | ||||
| 36. Round | 21/10/2022 | Treaty United | - | Wexford FC | 0:2 |
Ireland