| 3. Round | 09/02/2022 | Real Madriz | - | Juventus Managua | 0:3 |  |
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| 5. Round | 19/02/2022 | Juventus Managua | - | H&H Export Sébaco | 5:1 | ||||
| 8. Round | 07/03/2022 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 13. Round | 07/04/2022 | Juventus Managua | - | Real Estelí FC | 0:3 | ||||
| 14. Round | 09/04/2022 | H&H Export Sébaco | - | Juventus Managua | 2:0 | ||||
| 16. Round | 25/04/2022 | Juventus Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 18. Round | 01/05/2022 | Juventus Managua | - | UNAN Managua | 1:3 |  |
Nicaragua