| 1. Round | 10/07/2022 | H&H Export Sébaco | - | Juventus Managua | 0:0 | ||||
| 2. Round | 17/07/2022 | Juventus Managua | - | Managua FC | 2:1 | ||||
| 3. Round | 24/07/2022 | Juventus Managua | - | Matagalpa FC | 3:2 | ||||
| 4. Round | 31/07/2022 | Diriangén FC | - | Juventus Managua | 2:0 | ||||
| 5. Round | 08/08/2022 | Juventus Managua | - | Real Estelí FC | 0:0 | ||||
| 6. Round | 12/08/2022 | UNAN Managua | - | Juventus Managua | 2:1 | ||||
| 7. Round | 14/08/2022 | Juventus Managua | - | CD Walter Ferretti | 0:1 | ||||
| 12. Round | 01/10/2022 | Matagalpa FC | - | Juventus Managua | 2:5 |
Nicaragua