| 2. Round | 10/07/2016 | Atlético Junior | - | Independiente Medellín | 1:1 | ||||
| 3. Round | 13/07/2016 | Independiente Medellín | - | Envigado FC | 0:1 | ||||
| 4. Round | 16/07/2016 | Cortuluá | - | Independiente Medellín | 3:4 |  |
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| 5. Round | 24/07/2016 | Independiente Medellín | - | La Equidad | 1:0 |  |
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| 6. Round | 01/08/2016 | Independiente Medellín | - | Atlético Huila | 2:1 | ||||
| 8. Round | 13/08/2016 | Independiente Medellín | - | Patriotas FC | 3:0 | |
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| 9. Round | 21/08/2016 | Santa Fe | - | Independiente Medellín | 1:1 | |
Colombia