| 4. Round | 12/08/2018 | Deportivo Cali | - | Independiente Medellín | 3:2 | ||||
| 5. Round | 19/08/2018 | Independiente Medellín | - | Águilas Doradas | 1:0 |  |
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| 6. Round | 26/08/2018 | Atlético Junior | - | Independiente Medellín | 2:1 | ||||
| 7. Round | 02/09/2018 | Independiente Medellín | - | Once Caldas | 2:2 | ||||
| 8. Round | 07/09/2018 | La Equidad | - | Independiente Medellín | 1:1 | |
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| 9. Round | 09/09/2018 | Independiente Medellín | - | Leones FC | 1:1 | ||||
| 19. Round | 11/11/2018 | Independiente Medellín | - | Envigado FC | 2:2 |
Colombia