| 1. Round | 26/01/2019 | Patriotas FC | - | Independiente Medellín | 2:1 | ||||
| 2. Round | 30/01/2019 | Independiente Medellín | - | La Equidad | 1:1 | ||||
| 3. Round | 02/02/2019 | Atlético Junior | - | Independiente Medellín | 3:2 |  |
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| 5. Round | 16/02/2019 | América de Cali | - | Independiente Medellín | 3:0 | ||||
| 6. Round | 24/02/2019 | Independiente Medellín | - | Deportivo Cali | 1:1 |  |
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| 7. Round | 28/02/2019 | Águilas Doradas | - | Independiente Medellín | 0:1 | ||||
| 9. Round | 10/03/2019 | Independiente Medellín | - | Santa Fe | 1:0 | |
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| 10. Round | 16/03/2019 | Independiente Medellín | - | Atlético Nacional | 2:2 | |
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| 11. Round | 24/03/2019 | Independiente Medellín | - | Envigado FC | 4:1 | |
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| 16. Round | 28/03/2019 | Cúcuta Deportivo | - | Independiente Medellín | 2:2 | ||||
| 12. Round | 31/03/2019 | Millonarios | - | Independiente Medellín | 3:2 | ||||
| 13. Round | 05/04/2019 | Independiente Medellín | - | Once Caldas | 1:1 | ||||
| 17. Round | 20/04/2019 | Independiente Medellín | - | Jaguares de Córdoba | 3:0 | |
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| 8. Round | 25/04/2019 | Atlético Nacional | - | Independiente Medellín | 1:0 | |
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| 19. Round | 02/05/2019 | Independiente Medellín | - | Atlético Huila | 2:1 | |
Colombia