| 5. Round | 14/08/2021 | Independiente Medellín | - | América de Cali | 2:0 | ||||
| 6. Round | 22/08/2021 | Millonarios | - | Independiente Medellín | 2:0 | ||||
| 7. Round | 29/08/2021 | Atlético Huila | - | Independiente Medellín | 3:1 | ||||
| 9. Round | 11/09/2021 | Jaguares de Córdoba | - | Independiente Medellín | 0:1 |  |
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| 11. Round | 27/09/2021 | Deportes Quindío | - | Independiente Medellín | 1:0 | ||||
| 12. Round | 04/10/2021 | Independiente Medellín | - | Atlético Bucaramanga | 1:0 | ||||
| 13. Round | 09/10/2021 | Independiente Medellín | - | Envigado FC | 0:0 | ||||
| 15. Round | 24/10/2021 | Independiente Medellín | - | Deportes Tolima | 2:2 | |
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| 16. Round | 27/10/2021 | Alianza Petrolera | - | Independiente Medellín | 3:0 | |
Colombia