| 1. Round | 01/08/2021 | AD Chalatenango | - | Platense Zacatecoluca | 2:2 | ||||
| 5. Round | 21/08/2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 7. Round | 29/08/2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 9. Round | 16/09/2021 | AD Chalatenango | - | FAS | 1:2 | ||||
| 10. Round | 19/09/2021 | AD Chalatenango | - | Municipal Limeño | 1:1 | ||||
| 11. Round | 26/09/2021 | Isidro Metapán | - | AD Chalatenango | 1:4 |  |
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| 13. Round | 18/10/2021 | AD Chalatenango | - | Atlético Marte | 2:2 | ||||
| 14. Round | 21/10/2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 15. Round | 24/10/2021 | AD Chalatenango | - | Santa Tecla FC | 0:2 | |
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| 17. Round | 03/11/2021 | AD Chalatenango | - | CD Águila | 1:1 | ||||
| 18. Round | 07/11/2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Round | 14/11/2021 | AD Chalatenango | - | Jocoro FC | 2:0 | ||||
| 20. Round | 17/11/2021 | FAS | - | AD Chalatenango | 1:1 | |
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| 22. Round | 27/11/2021 | AD Chalatenango | - | Isidro Metapán | 1:0 |
El Salvador