| 1. Round | 21/02/2021 | Veraguas Club Deportivo | - | UD Universitario | 1:5 | ||||
| 2. Round | 27/02/2021 | UD Universitario | - | San Francisco FC | 3:2 | ||||
| 3. Round | 06/03/2021 | Atlético Chiriquí | - | UD Universitario | 1:1 | ||||
| 5. Round | 17/03/2021 | UD Universitario | - | Herrera FC | 4:0 | ||||
| 6. Round | 21/03/2021 | UD Universitario | - | Sporting San Miguelito | 2:1 | ||||
| 7. Round | 24/03/2021 | UD Universitario | - | Alianza | 1:1 | ||||
| 9. Round | 04/04/2021 | UD Universitario | - | Tauro FC | 1:0 | ||||
| 10. Round | 09/04/2021 | Árabe Unido | - | UD Universitario | 1:2 | ||||
| 12. Round | 20/04/2021 | UD Universitario | - | Veraguas Club Deportivo | 0:0 | ||||
| 16. Round | 08/05/2021 | Herrera FC | - | UD Universitario | 2:0 |  |
Panama