| 6. Round | 18/10/2020 | SK Dnipro-1 | - | Desna Chernigov | 2:0 | ||||
| 7. Round | 24/10/2020 | Olimpik Donetsk | - | Desna Chernigov | 0:2 | ||||
| 8. Round | 31/10/2020 | FK Oleksandriya | - | Desna Chernigov | 2:2 | ||||
| 9. Round | 07/11/2020 | Desna Chernigov | - | FC Mynai | 1:0 | ||||
| 10. Round | 22/11/2020 | Desna Chernigov | - | FK Lviv | 0:1 | ||||
| 11. Round | 29/11/2020 | Kolos Kovalivka | - | Desna Chernigov | 1:1 | ||||
| 12. Round | 06/12/2020 | Desna Chernigov | - | Vorskla Poltava | 1:0 | ||||
| 13. Round | 13/12/2020 | Desna Chernigov | - | FK Mariupol | 2:0 | ||||
| 14. Round | 13/02/2021 | Zorya Lugansk | - | Desna Chernigov | 2:1 | ||||
| 15. Round | 21/02/2021 | Desna Chernigov | - | Dinamo Kiev | 1:1 |  |
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| 18. Round | 14/03/2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:0 | ||||
| 22. Round | 17/04/2021 | FC Mynai | - | Desna Chernigov | 3:1 | ||||
| 23. Round | 24/04/2021 | FK Lviv | - | Desna Chernigov | 1:0 | ||||
| 25. Round | 05/05/2021 | Vorskla Poltava | - | Desna Chernigov | 1:1 | ||||
| 26. Round | 09/05/2021 | FK Mariupol | - | Desna Chernigov | 4:1 |
Georgia