| 1. Round | 07/08/2021 | Oldham Athletic | - | Newport County | 0:1 | ||||
| 2. Round | 14/08/2021 | Mansfield Town | - | Newport County | 2:1 | ||||
| 5. Round | 28/08/2021 | Salford City | - | Newport County | 3:0 | ||||
| 3. Round | 14/09/2021 | Newport County | - | Northampton Town | 0:1 | ||||
| 20. Round | 07/12/2021 | Newport County | - | Sutton United | 3:2 |  |
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| 21. Round | 11/12/2021 | Newport County | - | Port Vale FC | 2:1 | ||||
| 26. Round | 08/01/2022 | Newport County | - | Salford City | 0:2 | ||||
| 27. Round | 15/01/2022 | Newport County | - | Harrogate Town | 4:0 | ||||
| 24. Round | 25/01/2022 | Leyton Orient | - | Newport County | 0:1 | ||||
| 36. Round | 12/03/2022 | Stevenage FC | - | Newport County | 0:2 | ||||
| 37. Round | 15/03/2022 | Carlisle United | - | Newport County | 1:2 | ||||
| 40. Round | 02/04/2022 | Newport County | - | Exeter City | 0:1 | ||||
| 41. Round | 09/04/2022 | Swindon Town | - | Newport County | 0:1 | ||||
| 42. Round | 15/04/2022 | Newport County | - | Crawley Town | 1:2 | ||||
| 43. Round | 18/04/2022 | Sutton United | - | Newport County | 1:0 | ||||
| 44. Round | 22/04/2022 | Newport County | - | Colchester United | 1:2 | ||||
| 46. Round | 07/05/2022 | Newport County | - | Rochdale AFC | 0:2 |
Wales