| 12. Round | 02/10/2021 | Deportes Tolima | - | Santa Fe | 0:0 | ||||
| 13. Round | 09/10/2021 | Once Caldas | - | Deportes Tolima | 0:2 | ||||
| 14. Round | 16/10/2021 | Deportes Tolima | - | Atlético Huila | 1:0 | ||||
| 15. Round | 24/10/2021 | Independiente Medellín | - | Deportes Tolima | 2:2 | ||||
| 16. Round | 29/10/2021 | Deportes Tolima | - | América de Cali | 0:1 |  |
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| 19. Round | 15/11/2021 | Atlético Bucaramanga | - | Deportes Tolima | 1:1 |
Colombia