| 1. Round | 08/08/2021 | Atlético Chiriquí | - | San Francisco FC | 1:1 | ||||
| 2. Round | 15/08/2021 | Herrera FC | - | Atlético Chiriquí | 0:0 | ||||
| 3. Round | 22/08/2021 | Atlético Chiriquí | - | UD Universitario | 1:1 | ||||
| 5. Round | 05/09/2021 | Independiente de La Chorrera | - | Atlético Chiriquí | 1:2 | ||||
| 6. Round | 11/09/2021 | Alianza | - | Atlético Chiriquí | 2:1 | ||||
| 9. Round | 03/10/2021 | Plaza Amador | - | Atlético Chiriquí | 2:0 | ||||
| 11. Round | 16/10/2021 | Atlético Chiriquí | - | Sporting San Miguelito | 1:1 | ||||
| 12. Round | 23/10/2021 | San Francisco FC | - | Atlético Chiriquí | 1:0 | ||||
| 13. Round | 31/10/2021 | Atlético Chiriquí | - | Herrera FC | 0:0 | ||||
| 14. Round | 06/11/2021 | UD Universitario | - | Atlético Chiriquí | 4:1 |  |
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| 16. Round | 20/11/2021 | Atlético Chiriquí | - | Independiente de La Chorrera | 1:1 |
Colombia