| 1. Round | 23/07/2022 | UD Universitario | - | San Francisco FC | 1:0 |  |
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| 2. Round | 01/08/2022 | Atlético Chiriquí | - | UD Universitario | 3:2 | ||||
| 3. Round | 06/08/2022 | Veraguas United | - | UD Universitario | 0:3 | ||||
| 4. Round | 10/08/2022 | Herrera FC | - | UD Universitario | 2:2 | ||||
| 5. Round | 17/08/2022 | Independiente de La Chorrera | - | UD Universitario | 3:1 | ||||
| 6. Round | 21/08/2022 | Sporting San Miguelito | - | UD Universitario | 2:2 | |
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| 8. Round | 05/09/2022 | UD Universitario | - | Árabe Unido | 1:2 | ||||
| 9. Round | 11/09/2022 | UD Universitario | - | Alianza | 1:0 | |
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| 10. Round | 18/09/2022 | Tauro FC | - | UD Universitario | 1:2 | ||||
| 11. Round | 25/09/2022 | Plaza Amador | - | UD Universitario | 1:2 |  |
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| 13. Round | 03/10/2022 | UD Universitario | - | Atlético Chiriquí | 0:0 | ||||
| 14. Round | 10/10/2022 | UD Universitario | - | Veraguas United | 3:1 | |
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| 15. Round | 16/10/2022 | UD Universitario | - | Herrera FC | 2:0 | |
Panama