| 3. Round | 10/03/2022 | Academia Puerto Cabello | - | Aragua FC | 2:1 | ||||
| 4. Round | 18/03/2022 | Deportivo Táchira | - | Academia Puerto Cabello | 1:1 | ||||
| 5. Round | 25/03/2022 | Hermanos Colmenarez | - | Academia Puerto Cabello | 4:1 | ||||
| 6. Round | 01/04/2022 | Academia Puerto Cabello | - | Caracas FC | 0:0 | ||||
| 8. Round | 15/04/2022 | Academia Puerto Cabello | - | Monagas | 0:2 | ||||
| 9. Round | 24/04/2022 | Deportivo Lara | - | Academia Puerto Cabello | 1:2 | ||||
| 10. Round | 30/04/2022 | Academia Puerto Cabello | - | Estudiantes de Mérida | 1:0 | ||||
| 11. Round | 08/05/2022 | Universidad Central | - | Academia Puerto Cabello | 2:2 | ||||
| 12. Round | 15/05/2022 | Academia Puerto Cabello | - | Carabobo FC | 1:1 |  |
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| 14. Round | 29/05/2022 | Academia Puerto Cabello | - | Metropolitanos FC | 0:2 | |
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| 16. Round | 11/06/2022 | Academia Puerto Cabello | - | Zulia FC | 2:2 | ||||
| 17. Round | 19/06/2022 | Metropolitanos FC | - | Academia Puerto Cabello | 0:2 |  |
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| 18. Round | 04/07/2022 | Academia Puerto Cabello | - | Zamora FC | 0:0 | ||||
| 23. Round | 05/08/2022 | Monagas | - | Academia Puerto Cabello | 0:1 |  |
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| 26. Round | 27/08/2022 | Academia Puerto Cabello | - | Hermanos Colmenarez | 1:2 |
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