| 3. Round | 12/08/2017 | Sporting Lokeren | - | Royal Excel Mouscron | 0:2 | ||||
| 4. Round | 20/08/2017 | Royal Excel Mouscron | - | KAA Gent | 3:2 | ||||
| 5. Round | 25/08/2017 | KV Kortrijk | - | Royal Excel Mouscron | 1:1 | ||||
| 6. Round | 09/09/2017 | Royal Excel Mouscron | - | Club Brugge KV | 2:1 | ||||
| 7. Round | 17/09/2017 | SV Zulte Waregem | - | Royal Excel Mouscron | 2:1 |  |
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| 8. Round | 23/09/2017 | Royal Excel Mouscron | - | KAS Eupen | 3:2 | ||||
| 9. Round | 30/09/2017 | Royal Excel Mouscron | - | KV Mechelen | 2:2 | ||||
| 10. Round | 14/10/2017 | KRC Genk | - | Royal Excel Mouscron | 1:1 | ||||
| 11. Round | 20/10/2017 | Royal Excel Mouscron | - | Standard Liège | 1:3 | ||||
| 13. Round | 29/10/2017 | Royal Excel Mouscron | - | Royal Antwerp FC | 2:2 | ||||
| 14. Round | 04/11/2017 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 | ||||
| 15. Round | 18/11/2017 | Royal Excel Mouscron | - | RSC Anderlecht | 1:2 | ||||
| 22. Round | 19/01/2018 | Sporting Charleroi | - | Royal Excel Mouscron | 2:0 | ||||
| 23. Round | 23/01/2018 | Royal Excel Mouscron | - | KV Kortrijk | 0:3 | ||||
| 27. Round | 18/02/2018 | Royal Excel Mouscron | - | Waasland-Beveren | 2:2 | ||||
| 28. Round | 25/02/2018 | RSC Anderlecht | - | Royal Excel Mouscron | 5:3 | |
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