| 1. Round | 24/07/2021 | Oud-Heverlee Leuven | - | SV Zulte Waregem | 1:1 | ||||
| 2. Round | 01/08/2021 | SV Zulte Waregem | - | Standard Liège | 1:2 | ||||
| 3. Round | 07/08/2021 | Sint-Truidense VV | - | SV Zulte Waregem | 1:3 | ||||
| 4. Round | 15/08/2021 | SV Zulte Waregem | - | Club Brugge KV | 0:4 | ||||
| 5. Round | 22/08/2021 | SV Zulte Waregem | - | Sporting Charleroi | 2:2 | ||||
| 6. Round | 29/08/2021 | KV Oostende | - | SV Zulte Waregem | 0:2 | ||||
| 7. Round | 11/09/2021 | SV Zulte Waregem | - | Cercle Brugge | 2:4 | ||||
| 8. Round | 18/09/2021 | Union Saint-Gilloise | - | SV Zulte Waregem | 2:1 | ||||
| 9. Round | 25/09/2021 | SV Zulte Waregem | - | KV Kortrijk | 2:2 | ||||
| 28. Round | 19/02/2022 | KV Kortrijk | - | SV Zulte Waregem | 5:0 |
Belgium