| 1. Round | 09/08/2020 | SV Zulte Waregem | - | KRC Genk | 1:2 | ||||
| 3. Round | 23/08/2020 | Standard Liège | - | KRC Genk | 0:0 | ||||
| 4. Round | 30/08/2020 | KRC Genk | - | Club Brugge KV | 1:2 | ||||
| 5. Round | 14/09/2020 | K Beerschot VA | - | KRC Genk | 5:2 | ||||
| 6. Round | 20/09/2020 | KRC Genk | - | KV Mechelen | 3:1 | ||||
| 7. Round | 28/09/2020 | KRC Genk | - | KV Oostende | 2:2 | ||||
| 8. Round | 03/10/2020 | Waasland-Beveren | - | KRC Genk | 1:1 | ||||
| 13. Round | 22/11/2020 | KRC Genk | - | Royal Excel Mouscron | 4:1 | ||||
| 14. Round | 28/11/2020 | Cercle Brugge | - | KRC Genk | 1:5 | ||||
| 16. Round | 11/12/2020 | RSC Anderlecht | - | KRC Genk | 1:0 | ||||
| 21. Round | 24/01/2021 | Club Brugge KV | - | KRC Genk | 3:2 | ||||
| 23. Round | 30/01/2021 | KV Mechelen | - | KRC Genk | 0:0 | ||||
| 26. Round | 17/02/2021 | KV Oostende | - | KRC Genk | 3:1 | ||||
| 27. Round | 21/02/2021 | KRC Genk | - | K Beerschot VA | 1:2 | ||||
| 28. Round | 26/02/2021 | Sporting Charleroi | - | KRC Genk | 1:2 | ||||
| 31. Round | 19/03/2021 | KRC Genk | - | Standard Liège | 2:2 | ||||
| 33. Round | 11/04/2021 | KRC Genk | - | Sint-Truidense VV | 4:0 |
England