| 1. Round | 16/03/2021 | Almagro | - | Tristan Suárez | 1:3 | ||||
| 2. Round | 20/03/2021 | Gimnasia de Jujuy | - | Almagro | 1:2 | ||||
| 5. Round | 11/04/2021 | Almagro | - | Independiente Rivadavia | 0:2 | ||||
| 6. Round | 18/04/2021 | Atlético Rafaela | - | Almagro | 4:1 |  |
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| 8. Round | 30/04/2021 | Brown de Adrogué | - | Almagro | 2:0 | ||||
| 9. Round | 09/05/2021 | Almagro | - | San Martín de San Juan | 0:1 | ||||
| 12. Round | 17/06/2021 | Defensores de Belgrano | - | Almagro | 1:0 | ||||
| 13. Round | 22/06/2021 | Almagro | - | Ramón Santamarina | 1:1 | ||||
| 14. Round | 27/06/2021 | Almagro | - | All Boys | 3:0 | ||||
| 18. Round | 24/07/2021 | Tristan Suárez | - | Almagro | 1:1 | ||||
| 24. Round | 04/09/2021 | Guillermo Brown | - | Almagro | 1:0 | ||||
| 28. Round | 01/10/2021 | San Telmo | - | Almagro | 2:1 | ||||
| 34. Round | 15/11/2021 | Almagro | - | Ferro Carril Oeste | 2:3 |  |
Argentina