| 2. Round | 16/07/2022 | Fortaleza FC | - | Cúcuta Deportivo | 2:2 | ||||
| 3. Round | 24/07/2022 | Cúcuta Deportivo | - | Barranquilla FC | 0:1 | ||||
| 4. Round | 29/07/2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 5. Round | 05/08/2022 | Bogotá FC | - | Cúcuta Deportivo | 2:1 | ||||
| 6. Round | 09/08/2022 | Cúcuta Deportivo | - | Boyacá Chicó | 1:2 |  |
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| 10. Round | 04/09/2022 | Cúcuta Deportivo | - | Orsomarso SC | 3:0 | ||||
| 15. Round | 02/10/2022 | Atlético FC | - | Cúcuta Deportivo | 0:1 |  |
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| 16. Round | 08/10/2022 | Cúcuta Deportivo | - | Tigres FC | 2:1 |  |
Argentina