| 2. Round | 29/08/2021 | AC Ajaccio [Youth] | - | OGC Nice [Youth] | 0:3 |  |
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| 3. Round | 05/09/2021 | OGC Nice [Youth] | - | Nîmes Olympique [Youth] | 1:1 | ||||
| 4. Round | 12/09/2021 | Montpellier HSC [Youth] | - | OGC Nice [Youth] | 2:1 | ||||
| 5. Round | 18/09/2021 | OGC Nice [Youth] | - | AS Béziers [Youth] | 2:2 | ||||
| 6. Round | 26/09/2021 | SC Toulon [Youth] | - | OGC Nice [Youth] | 0:1 | ||||
| 9. Round | 16/10/2021 | OGC Nice [Youth] | - | AS Saint-Étienne [Youth] | 4:3 | ||||
| 10. Round | 23/10/2021 | OGC Nice [Youth] | - | Toulouse FC [Youth] | 1:2 | ||||
| 17. Round | 06/02/2022 | AS Béziers [Youth] | - | OGC Nice [Youth] | 0:0 | ||||
| 18. Round | 13/02/2022 | OGC Nice [Youth] | - | SC Toulon [Youth] | 2:0 | ||||
| 19. Round | 06/03/2022 | Olympique Marseille [Youth] | - | OGC Nice [Youth] | 4:1 | ||||
| 20. Round | 12/03/2022 | OGC Nice [Youth] | - | AS Cannes [Youth] | 2:0 | ||||
| 22. Round | 02/04/2022 | Toulouse FC [Youth] | - | OGC Nice [Youth] | 5:1 | |
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| 23. Round | 09/04/2022 | OGC Nice [Youth] | - | FC Istres [Youth] | 4:0 | |
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| 24. Round | 17/04/2022 | Pieve di Lota [Youth] | - | OGC Nice [Youth] | 1:6 | ||||
| 25. Round | 01/05/2022 | OGC Nice [Youth] | - | AS Monaco [Youth] | 3:5 |
France