| 1. Round | 05/02/2022 | Deportivo Municipal | - | Ayacucho FC | 3:2 |  |
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| 2. Round | 13/02/2022 | Cienciano | - | Deportivo Municipal | 4:2 | ||||
| 3. Round | 19/02/2022 | Deportivo Municipal | - | Deportivo Binacional | 1:0 | ||||
| 4. Round | 27/02/2022 | AD Tarma | - | Deportivo Municipal | 2:3 |  |
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| 5. Round | 05/03/2022 | Deportivo Municipal | - | Universitario de Deportes | 2:1 | ||||
| 6. Round | 13/03/2022 | Sport Boys | - | Deportivo Municipal | 1:2 | |
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| 7. Round | 20/03/2022 | Deportivo Municipal | - | Atlético Grau | 1:1 | ||||
| 8. Round | 02/04/2022 | Alianza Atlético | - | Deportivo Municipal | 2:2 | ||||
| 9. Round | 09/04/2022 | Deportivo Municipal | - | Mannucci | 1:0 | |
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| 10. Round | 16/04/2022 | Sporting Cristal | - | Deportivo Municipal | 6:4 | ||||
| 11. Round | 22/04/2022 | Deportivo Municipal | - | FBC Melgar | 1:3 | |
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| 14. Round | 14/05/2022 | Universidad Técnica | - | Deportivo Municipal | 4:3 | |
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| 15. Round | 22/05/2022 | Deportivo Municipal | - | Alianza Lima | 0:3 | ||||
| 16. Round | 29/05/2022 | Academia Cantolao | - | Deportivo Municipal | 0:2 | ||||
| 17. Round | 18/06/2022 | Deportivo Municipal | - | Carlos Stein | 1:1 |
Argentina