| 1. Round | 14/08/2022 | KRC Genk II | - | Lierse Kempenzonen | 4:1 | ||||
| 2. Round | 21/08/2022 | Lierse Kempenzonen | - | Club NXT | 3:1 | ||||
| 4. Round | 03/09/2022 | Lierse Kempenzonen | - | KMSK Deinze | 4:1 | ||||
| 5. Round | 09/09/2022 | FCV Dender EH | - | Lierse Kempenzonen | 2:3 | ||||
| 6. Round | 16/09/2022 | Lierse Kempenzonen | - | RSCA Futures | 2:3 | ||||
| 7. Round | 02/10/2022 | SK Beveren | - | Lierse Kempenzonen | 5:0 | ||||
| 8. Round | 09/10/2022 | Lierse Kempenzonen | - | Standard Liège II | 2:0 |  |
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| 9. Round | 15/10/2022 | Excelsior Virton | - | Lierse Kempenzonen | 0:0 | ||||
| 11. Round | 30/10/2022 | RWD Molenbeek | - | Lierse Kempenzonen | 3:0 | ||||
| 12. Round | 06/11/2022 | Lierse Kempenzonen | - | KRC Genk II | 4:2 | ||||
| 13. Round | 13/11/2022 | Lierse Kempenzonen | - | SK Beveren | 1:5 | ||||
| 14. Round | 20/11/2022 | KMSK Deinze | - | Lierse Kempenzonen | 2:1 | ||||
| 15. Round | 27/11/2022 | Lierse Kempenzonen | - | Excelsior Virton | 2:2 | ||||
| 19. Round | 22/01/2023 | RSCA Futures | - | Lierse Kempenzonen | 3:3 | ||||
| 20. Round | 29/01/2023 | Lierse Kempenzonen | - | RWD Molenbeek | 1:2 |
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