| 1. Round | 21/01/2021 | Alianza Petrolera | - | Deportivo Pereira | 2:2 | ||||
| 3. Round | 29/01/2021 | Jaguares de Córdoba | - | Alianza Petrolera | 2:0 | ||||
| 4. Round | 03/02/2021 | Alianza Petrolera | - | Águilas Doradas | 1:2 | ||||
| 5. Round | 06/02/2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Round | 12/02/2021 | Alianza Petrolera | - | Once Caldas | 0:0 | ||||
| 7. Round | 16/02/2021 | Patriotas FC | - | Alianza Petrolera | 3:1 | ||||
| 17. Round | 07/04/2021 | Alianza Petrolera | - | Santa Fe | 0:3 | ||||
| 18. Round | 10/04/2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 |
Colombia