| 1. Round | 16/01/2021 | Real Cartagena | - | Cortuluá | 2:1 |  |
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| 2. Round | 23/01/2021 | Atlético FC | - | Real Cartagena | 3:0 | |
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| 3. Round | 01/02/2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Round | 08/02/2021 | Valledupar FC | - | Real Cartagena | 2:0 | ||||
| 5. Round | 11/02/2021 | Real Cartagena | - | Llaneros FC | 3:1 | ||||
| 6. Round | 15/02/2021 | Unión Magdalena | - | Real Cartagena | 2:1 | ||||
| 7. Round | 19/02/2021 | Real Cartagena | - | Deportes Quindío | 2:3 | ||||
| 8. Round | 27/02/2021 | Orsomarso SC | - | Real Cartagena | 3:3 | ||||
| 9. Round | 03/03/2021 | Real Cartagena | - | Boca Juniors de Cali | 1:1 | ||||
| 11. Round | 14/03/2021 | Real Santander | - | Real Cartagena | 0:3 | ||||
| 12. Round | 22/03/2021 | Real Cartagena | - | Bogotá FC | 1:1 | ||||
| 14. Round | 02/04/2021 | Real Cartagena | - | Leones FC | 2:1 | ||||
| 15. Round | 09/04/2021 | Atlético Huila | - | Real Cartagena | 4:1 |
Colombia