| 12. Round | 13/03/2022 | Municipal Limeño | - | Luis Ángel Firpo | 3:2 | ||||
| 14. Round | 24/03/2022 | Isidro Metapán | - | Luis Ángel Firpo | 1:1 |  |
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| 15. Round | 03/04/2022 | Luis Ángel Firpo | - | AD Chalatenango | 1:2 | ||||
| 16. Round | 10/04/2022 | Luis Ángel Firpo | - | Alianza | 0:1 | ||||
| 17. Round | 13/04/2022 | Platense Zacatecoluca | - | Luis Ángel Firpo | 1:2 | ||||
| 18. Round | 17/04/2022 | Luis Ángel Firpo | - | Once Municipal | 0:0 | ||||
| 19. Round | 24/04/2022 | CD Águila | - | Luis Ángel Firpo | 1:0 | ||||
| 20. Round | 28/04/2022 | Luis Ángel Firpo | - | Jocoro FC | 1:0 | ||||
| 21. Round | 01/05/2022 | FAS | - | Luis Ángel Firpo | 0:1 | ||||
| 22. Round | 07/05/2022 | Luis Ángel Firpo | - | Santa Tecla FC | 2:0 |
El Salvador