| 1. Round | 31/07/2021 | CSD Municipal | - | Deportivo Guastatoya | 1:0 | ||||
| 2. Round | 07/08/2021 | Santa Lucía | - | CSD Municipal | 1:1 |  |
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| 6. Round | 25/08/2021 | CSD Municipal | - | Sololá FC | 2:3 |  |
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| 7. Round | 29/08/2021 | Nueva Concepción | - | CSD Municipal | 0:2 | ||||
| 9. Round | 11/09/2021 | Comunicaciones | - | CSD Municipal | 2:1 | ||||
| 13. Round | 09/10/2021 | CSD Municipal | - | Santa Lucía | 1:1 | ||||
| 11. Round | 14/10/2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| 14. Round | 17/10/2021 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 15. Round | 23/10/2021 | Iztapa | - | CSD Municipal | 1:0 | ||||
| 18. Round | 06/11/2021 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Round | 14/11/2021 | Achuapa | - | CSD Municipal | 0:1 | ||||
| 20. Round | 20/11/2021 | CSD Municipal | - | Comunicaciones | 0:0 |
Guatemala