Round of 16 | 09/04/2021 | Real Estelí FC | - | Columbus Crew | 0:4 | ||||
Round of 16 | 16/04/2021 | Columbus Crew | - | Real Estelí FC | 1:0 | ||||
Quarter-finals | 29/04/2021 | Columbus Crew | - | CF Monterrey | 2:2 | ||||
Quarter-finals | 06/05/2021 | CF Monterrey | - | Columbus Crew | 3:0 |