| 2. Round | 15/01/2022 | Municipal Grecia | - | CS Herediano | 1:1 | ||||
| 3. Round | 23/01/2022 | Santos de Guápiles | - | CS Herediano | 0:0 | ||||
| 4. Round | 04/02/2022 | CS Herediano | - | Deportivo Saprissa | 1:1 | ||||
| 5. Round | 11/02/2022 | AD San Carlos | - | CS Herediano | 1:1 | ||||
| 6. Round | 15/02/2022 | CS Herediano | - | Sporting FC | 0:1 | ||||
| 1. Round | 18/02/2022 | CS Herediano | - | Jicaral | 1:1 | ||||
| 7. Round | 20/02/2022 | CS Cartaginés | - | CS Herediano | 1:0 | ||||
| 8. Round | 27/02/2022 | CS Herediano | - | AD Guanacasteca | 1:2 | ||||
| 10. Round | 05/03/2022 | Guadalupe | - | CS Herediano | 1:1 | ||||
| 11. Round | 01/04/2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 |  |
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| 12. Round | 05/04/2022 | Jicaral | - | CS Herediano | 0:3 | |
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| 13. Round | 10/04/2022 | CS Herediano | - | Municipal Grecia | 3:1 | ||||
| 15. Round | 21/04/2022 | Deportivo Saprissa | - | CS Herediano | 0:1 | ||||
| 16. Round | 24/04/2022 | CS Herediano | - | AD San Carlos | 1:1 | ||||
| 18. Round | 01/05/2022 | CS Herediano | - | CS Cartaginés | 4:1 | ||||
| 19. Round | 04/05/2022 | AD Guanacasteca | - | CS Herediano | 0:1 | ||||
| 21. Round | 13/05/2022 | CS Herediano | - | Guadalupe | 0:0 | ||||
| 22. Round | 15/05/2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 |
Mexico