| 1. Round | 10/07/2022 | H&H Export Sébaco | - | Juventus Managua | 0:0 | ||||
| 2. Round | 17/07/2022 | CD Walter Ferretti | - | H&H Export Sébaco | 1:2 |  |
 |
||
| 3. Round | 24/07/2022 | H&H Export Sébaco | - | Real Estelí FC | 0:0 | ||||
| 4. Round | 31/07/2022 | Matagalpa FC | - | H&H Export Sébaco | 1:2 | |
|||
| 5. Round | 07/08/2022 | H&H Export Sébaco | - | UNAN Managua | 5:0 | |
|||
| 6. Round | 11/08/2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 2:1 | |
|||
| 7. Round | 14/08/2022 | H&H Export Sébaco | - | Managua FC | 2:1 | |
|||
| 9. Round | 28/08/2022 | ART Municipal Jalapa | - | H&H Export Sébaco | 1:0 | ||||
| 10. Round | 04/09/2022 | Juventus Managua | - | H&H Export Sébaco | 1:1 | ||||
| 11. Round | 11/09/2022 | H&H Export Sébaco | - | CD Walter Ferretti | 1:1 | |
|||
| 12. Round | 03/10/2022 | Real Estelí FC | - | H&H Export Sébaco | 3:1 | |
|||
| 13. Round | 23/10/2022 | H&H Export Sébaco | - | Matagalpa FC | 2:1 | |
|||
| 14. Round | 27/10/2022 | UNAN Managua | - | H&H Export Sébaco | 0:0 | |
|||
| 15. Round | 30/10/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:0 | |
Nicaragua